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Annals of Medicine and Medical Education
Volume 1, Issue 1 (March 2014), pp. 8-13

DOI: 10.12973/ejms.2014.102p

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Research Article

Published online on Apr 02, 2014

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Neutrophil-to-lymphocyte ratio in diabetes mellitus patients with and without diabetic foot ulcer

Cüneyt Kahraman, Gündüz Yümün, Nilüfer Kuzeyli Kahraman, Nazli Dizen Namdar, Süleyman Cosgun


Background: Diabetes mellitus (DM), with the cost of treatment and complications causes the increasing economic burden. Inflammation in the pathogenesis of type 2 DM and developing complications are considered to have a role. Macrovascular complications of diabetes, diabetic foot ulcers and amputations consequently reduce quality of life is seriously. Atherosclerosis and related complications is considered as an inflammatory process. To show the severity and course of this inflammatory process, the studies including many markers are available. Recently, it is reported as a cheap and accessible marker, neutrophil/lymphocyte ratio (NLR) is a good indicator of the inflammatory condition. The aim of this study to investigate the relationship between the presence of the diabetic foot and neutrophil / lymphocyte ratio. Methods: It has been noted retrospectively the charts of the data of internal medicine clinic patients with diabetes. Patients' age, sex, duration of diabetes, blood count and biochemical parameters were recorded. The data of patients with and without diabetic foot ulcers were assessed using SPSS 19.0. Results: Statistically significant differences were also observed according to HbA1c (P = 0.006), serum urea (P = 0.042), CRP (P < 0.001), neutrophil percent (P < 0.001), lymphocyte percent (P < 0.001), NLR (P = 0.001), among the 2 groups. A correlation was determined between NLR and age, serum urea, creatinine, white blood cell (WBC), neutrophil percent, lymphocyte percent, total cholesterol, HDL-cholesterol. Conclusion: The presence of diabetic foot ulcers alone may also represent a systemic inflammatory response. NLR can be a cheap and accessible marker for presence of this inflammatory process via using the response rates and follow-up of patients.

Key Words: Diabetic foot ulcermacrovascular complications, neutrophil/lymphocyte ratio.

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