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Eurasian Journal of Analytical Chemistry
Volume 12, Issue 4 (July 2017), pp. 337-364

DOI: 10.12973/ejac.2017.00174a

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Review Article

Published online on Jan 04, 2017

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A Concise Review on Analytical Profile of Valsartan

Atul A. Shirkhedkar, Suraj R. Chaudhari, Amod S. Patil, & Sanjay J. Surana

Abstract

Valsartan (VAL) is an orally active angiotensin-II receptor type-I antagonist. VAL is available alone in dosage form as well as multicomponent formulation with various antihypertensive drugs like nifedipine, hydrochlorothiazide, ramipril, amlodipine and nebivolol hydrochloride, for the management of hypertension. The present investigation assesses the various approaches for analysis of VAL in bulk drug as well as formulated products. A concise review represents the compilation and discussion of about more than 90 analytical methods which includes HPLC, HPTLC, capillary electrophoresis, electrochemical methods and UV-Spectrophotometry methods implemented for investigation of VAL in biological matrices, bulk samples and in different dosage formulations. The review describes the percentage utilization of the various approaches for analysis of VAL. The statistical data regarding the utility of these methods for estimation of VAL published during 2001 to 2016 have been included.

Keywords: chromatography, valsartan, method validation, review article, bioanalysis


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